Learner's definition of SETUP
1 : the process of making something (such as a machine or computer program) ready to be used
[noncount]— often used before another noun
2 [count] : the way that something is done or organized
It took me a while to learn the setup of the office's filing system.
We had a great setup. On my days off, my wife would work from home while I took care of the kids.
The software makes it easy to create custom setups.
3 [count], informal : a situation in which someone is deliberately put in a bad position or made to look guilty— usually singular 4 [count] : the beginning of a story, joke, etc., that explains and leads to what follows— usually singular
— see also set up at 1set