Learner's definition of REGARDLESS
: in spite of difficulty, trouble, etc. : without being stopped by difficulty, trouble, etc.
It may rain, but I will go regardless. [=I will go even if it rains; I will not be stopped from going]
It was raining, but we went for a walk regardless. [=anyway]
: without being stopped or affected by (something)
He runs every day regardless of the weather. [=he runs every day no matter what the weather is like]
Regardless of [=despite] our request, he would not alter his plans.